High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity. 28 May Dr D Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts.