The antinociceptive effect of 2-chloro-2′-C-methyl-N6-cyclopentyladenosine (2′-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat. 16 Jul Dr D Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways. Cannabidiol–recent advances.