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Endocannabinoid pumps and bowel inflammation

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Endocannabinoid pumps and bowel inflammation

Endocannabinoid pumps and bowel inflammation

Apr 1, 2019 Written by Dr D

Inflammatory diseases of the bowel have been notoriously hard to treat in many cases, with some patients seemingly suffering far more than others for no apparent reason.

The below 2019 paper is an animal study showing animal gut tissue pumping endocannabinoids into the bowel lumen with a beneficial effect of reduced neutrophil transmigration. From this paper and citations one can hypothesize that indeed endocannabinoid pumps in the gut may offer an increased understanding of IBS, explain some of cannabinoids beneficial effects in bowel disease, and offer hope for new therapeutic targets.

https://www.ncbi.nlm.nih.gov/pubmed/30102254